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((4-羟基丁基)氮杂二烷基)双(己烷-6,1-二基)双(2-己基癸酸酯)

((4-羟基丁基)氮杂二烷基)双(己烷-6,1-二基)双(2-己基癸酸酯)

产品简称:ALC-0315(DHA)CAS no.:2036272-55-4
分子量:766包装尺寸:1g, 5g, 10g, 100g, 1kg, 10kg储存:-20±5℃
CAS no. 分子量(Mp) 产品编码
2036272-55-4 766 06040008600


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1. Deng X, Yang Y, Gan L, et al. Engineering Lipid Nanoparticles to Enhance Intracellular Delivery of Transforming Growth Factor-Beta siRNA (siTGF-β1) via Inhalation for Improving Pulmonary Fibrosis Post-Bleomycin Challenge. Pharmaceutics. 2025;17(2):157. Published 2025 Jan 24. doi:10.3390/pharmaceutics17020157
2. Nguyen CM, Vu TT, Nguyen MN, et al. Neoantigen-d mRNA vaccine exhibits superior anti-tumor activity compared to synthetic long peptides in an in vivo lung carcinoma model. Cancer Immunol Immunother. 2025;74(4):145. Published 2025 Mar 12. doi:10.1007/s00262-025-03992-7
3. Cheng X, Zheng X, Tao K, et al. Freezing induced incorporation of betaine in lipid nanoparticles enhances mRNA delivery. Nat Commun. 2025;16(1):4700. Published 2025 May 20. doi:10.1038/s41467-025-60040-9
4. Liu S, Wen Y, Shan X, et al. Charge-assisted stabilization of lipid nanoparticles enables inhaled mRNA delivery for mucosal vaccination. Nat Commun. 2024;15(1):9471. Published 2024 Nov 2. doi:10.1038/s41467-024-53914-x
5. Kozlova A, Pateev I, Shepelkova G, et al. A Cap-Optimized mRNA Encoding Multiepitope Antigen ESAT6 Induces Robust Cellular and Humoral Immune Responses Against Mycobacterium tuberculosis. Vaccines (l). 2024;12(11):1267. Published 2024 Nov 9. doi:10.3390/vaccines12111267

6. Jiang L, Zhou W, Liu F, et al. An mRNA Vaccine for Herpes Zoster and Its Efficacy Evaluation in Naïve/Primed Murine Models. Vaccines (l). 2025;13(3):327. Published 2025 Mar 19. doi:10.3390/vaccines13030327
7. Li M, Zheng X, Yu X, et al. Potentiating the Efficacy of mRNA Vaccines through NIR-II Imaging-Guided Precise Vaccination. Adv Sci (Weinh). 2025;12(37):e13014. doi:10.1002/advs.202413014
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9. Liu D, Wang X, Xu L, et al. Screening lipid nanoparticles using DNA barcoding and qPCR. Colloids Surf B Biointerfaces. 2025;251:114598. doi:10.1016/j.colsurfb.2025.114598
10. Ao D, Peng D, He C, et al. A promising mRNA vaccine derived from the JN.1 spike protein confers protective immunity against multiple emerged Omicron variants. Mol Biomed. 2025;6(1):13. Published 2025 Mar 4. doi:10.1186/s43556-025-00258-7

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19. Sui, Meihua & Wang, Yisha & Luo, Gan & Wang, Haiyang & Zheng, Yue & Zhou, Wenbin & Lin, Junrong & Chen, Baocheng. (2024). Construction and Application of a Technical Platform for Determining Cell Cycle- and Autophagy-Associated Cellular Uptake of Lipid-d Nanoparticles. 10.21203/rs.3.rs-3974581/v1.
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关键词:LNP脂质DHA辉瑞疫苗Prizer新冠疫苗辅料

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